Drug Delivery

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Particle Size Analysis of Pharmaceutical Sugar Spheres (Multiparticulates)
Many solid oral dosage forms are based upon coating sugar spheres with layers of active ingredient, binders, and coatings. The size and shape of the beginning sugar spheres (also called nonpareil beads) are critical physical characteristics that should be carefully measured and controlled.
Particle Size Analysis of Nanoparticles for Drug Delivery
The LA-960 Particle Size Analyzer and SZ-100 Nanoparticle Analyzer may be used to measure the particle size distribution and zeta potential for drug delivery vehicles. These characteristics directly affect bioavailability, dissolution, immunotoxicity, amongst other critical formulation factors.
The Detection of a Low Molecular Weight Enzyme Inhibitor using the OpenPlex? system
The use of low molecular weight molecules in the industries of drug discovery and agri-food has become increasingly important over the course of a century of drug research and science development in agriculture and in pharmaceutical field.
The Detection of an Ultralow Molecular Weight Enzyme Inhibitor using the XelPleX system
Detection of low molecular weight molecules can be useful especially for pharmaceutical and agri-food applications. This application note is focused on the detection of a 157 Dalton molecule, the benzenesulfonamide, using the XelPleX system. The benzenesulfonamide is an inhibitor of the human carbonic anhydrase enzyme type II (CAII).
Determination of the Roundness of Globules in the Pharmaceutical Industry
For determination of grain size and roundness of globules, quick and objective measurement methods are required to guarantee high analytical accuracy as well as high product throughput.
Analysis of Biopolymers with Laser Diffraction
This application note describes two experiments where laser diffraction proved capable of determining both the base biopolymer nanoparticles and also larger particles outside of the range of DLS.
Investigating photocleavage using time‐resolved emission spectra
The choice of protecting group is of crucial importance in the success of many steps in organic synthesis and the manipulation of polyfunctional molecules, since they can prevent the formation of undesired side products and reactions.